A Large-Scale Mutational Analysis of Two-Component Signaling Systems of Lonsdalea quercina Revealed that KdpD-KdpE Regulates Bacterial Virulence Against Host Poplar Trees.
Identifieur interne : 001088 ( Main/Exploration ); précédent : 001087; suivant : 001089A Large-Scale Mutational Analysis of Two-Component Signaling Systems of Lonsdalea quercina Revealed that KdpD-KdpE Regulates Bacterial Virulence Against Host Poplar Trees.
Auteurs : Ruo-Lan Yang [République populaire de Chine] ; Chao-Ying Deng ; Jin-Wei Wei [République populaire de Chine] ; Wei He [République populaire de Chine] ; Ai-Ning Li [République populaire de Chine] ; Wei QianSource :
- Molecular plant-microbe interactions : MPMI [ 0894-0282 ] ; 2018.
Descripteurs français
- KwdFr :
- ADN bactérien (génétique), Analyse de mutations d'ADN (MeSH), Bactéries à Gram négatif (génétique), Bactéries à Gram négatif (pathogénicité), Bactéries à Gram négatif (physiologie), Maladies des plantes (microbiologie), Populus (microbiologie), Protéines bactériennes (génétique), Protéines bactériennes (métabolisme), Régulation de l'expression des gènes bactériens (physiologie), Transduction du signal (physiologie), Virulence (MeSH).
- MESH :
- génétique : ADN bactérien, Bactéries à Gram négatif, Protéines bactériennes.
- microbiologie : Maladies des plantes, Populus.
- métabolisme : Protéines bactériennes.
- pathogénicité : Bactéries à Gram négatif.
- physiologie : Bactéries à Gram négatif, Régulation de l'expression des gènes bactériens, Transduction du signal.
- Analyse de mutations d'ADN, Virulence.
English descriptors
- KwdEn :
- Bacterial Proteins (genetics), Bacterial Proteins (metabolism), DNA Mutational Analysis (MeSH), DNA, Bacterial (genetics), Gene Expression Regulation, Bacterial (physiology), Gram-Negative Bacteria (genetics), Gram-Negative Bacteria (pathogenicity), Gram-Negative Bacteria (physiology), Plant Diseases (microbiology), Populus (microbiology), Signal Transduction (physiology), Virulence (MeSH).
- MESH :
- chemical , genetics : Bacterial Proteins, DNA, Bacterial.
- chemical , metabolism : Bacterial Proteins.
- genetics : Gram-Negative Bacteria.
- microbiology : Plant Diseases, Populus.
- pathogenicity : Gram-Negative Bacteria.
- physiology : Gene Expression Regulation, Bacterial, Gram-Negative Bacteria, Signal Transduction.
- DNA Mutational Analysis, Virulence.
Abstract
Poplar, which is a dominant species in plant communities distributed in the northern hemisphere, is commonly used as a model plant in forestry studies. Poplar production can be inhibited by infections caused by bacteria, including Lonsdalea quercina subsp. populi, which is a gram-negative bacterium responsible for bark canker disease. However, the molecular basis of the pathogenesis remains uncharacterized. In this study, we annotated the two-component signal transduction systems (TCSs) encoded by the L. quercina subsp. populi N-5-1 genome and identified 18 putative histidine kinases and 24 response regulators. A large-scale mutational analysis revealed that 19 TCS genes regulated bacterial virulence against poplar trees. Additionally, the deletion of kdpE or overexpression of kdpD resulted in almost complete loss of bacterial virulence. We observed that kdpE and kdpD formed a bi-cistronic operon. KdpD exhibited autokinase activity and could bind to KdpE (Kd = 5.73 ± 0.64 μM). Furthermore, KdpE is an OmpR family response regulator. A chromatin immunoprecipitation sequencing analysis revealed that KdpE binds to an imperfect palindromic sequence within the promoters of 44 genes, including stress response genes Lqp0434, Lqp3037, and Lqp3270. A comprehensive analysis of TCS functions may help to characterize the regulation of poplar bark canker disease.
DOI: 10.1094/MPMI-10-17-0248-R
PubMed: 29424663
Affiliations:
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and.</nlm:affiliation><wicri:noCountry code="subField">China; and</wicri:noCountry></affiliation></author><author><name sortKey="Deng, Chao Ying" sort="Deng, Chao Ying" uniqKey="Deng C" first="Chao-Ying" last="Deng">Chao-Ying Deng</name><affiliation><nlm:affiliation>2 State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; and.</nlm:affiliation><wicri:noCountry code="subField">China; and</wicri:noCountry></affiliation></author><author><name sortKey="Wei, Jin Wei" sort="Wei, Jin Wei" uniqKey="Wei J" first="Jin-Wei" last="Wei">Jin-Wei Wei</name><affiliation><nlm:affiliation>2 State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; and.</nlm:affiliation><wicri:noCountry code="subField">China; and</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:affiliation>3 School of Biological Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>3 School of Biological Sciences, University of Chinese Academy of Sciences, Beijing 100049</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="He, Wei" sort="He, Wei" uniqKey="He W" first="Wei" last="He">Wei He</name><affiliation wicri:level="1"><nlm:affiliation>1 The College of Forestry, Beijing Forestry University, Beijing 100083, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1 The College of Forestry, Beijing Forestry University, Beijing 100083</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Ai Ning" sort="Li, Ai Ning" uniqKey="Li A" first="Ai-Ning" last="Li">Ai-Ning Li</name><affiliation wicri:level="1"><nlm:affiliation>1 The College of Forestry, Beijing Forestry University, Beijing 100083, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1 The College of Forestry, Beijing Forestry University, Beijing 100083</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Qian, Wei" sort="Qian, Wei" uniqKey="Qian W" first="Wei" last="Qian">Wei Qian</name><affiliation><nlm:affiliation>2 State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; and.</nlm:affiliation><wicri:noCountry code="subField">China; and</wicri:noCountry></affiliation></author></analytic><series><title level="j">Molecular plant-microbe interactions : MPMI</title><idno type="ISSN">0894-0282</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bacterial Proteins (genetics)</term><term>Bacterial Proteins (metabolism)</term><term>DNA Mutational Analysis (MeSH)</term><term>DNA, Bacterial (genetics)</term><term>Gene Expression Regulation, Bacterial (physiology)</term><term>Gram-Negative Bacteria (genetics)</term><term>Gram-Negative Bacteria (pathogenicity)</term><term>Gram-Negative Bacteria (physiology)</term><term>Plant Diseases (microbiology)</term><term>Populus (microbiology)</term><term>Signal Transduction (physiology)</term><term>Virulence (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN bactérien (génétique)</term><term>Analyse de mutations d'ADN (MeSH)</term><term>Bactéries à Gram négatif (génétique)</term><term>Bactéries à Gram négatif (pathogénicité)</term><term>Bactéries à Gram négatif (physiologie)</term><term>Maladies des plantes (microbiologie)</term><term>Populus (microbiologie)</term><term>Protéines bactériennes (génétique)</term><term>Protéines bactériennes (métabolisme)</term><term>Régulation de l'expression des gènes bactériens (physiologie)</term><term>Transduction du signal (physiologie)</term><term>Virulence (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Bacterial Proteins</term><term>DNA, Bacterial</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Bacterial Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gram-Negative Bacteria</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN bactérien</term><term>Bactéries à Gram négatif</term><term>Protéines bactériennes</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Maladies des plantes</term><term>Populus</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Plant Diseases</term><term>Populus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines bactériennes</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Gram-Negative Bacteria</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Bactéries à Gram négatif</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Bactéries à Gram négatif</term><term>Régulation de l'expression des gènes bactériens</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gene Expression Regulation, Bacterial</term><term>Gram-Negative Bacteria</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>DNA Mutational Analysis</term><term>Virulence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de mutations d'ADN</term><term>Virulence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Poplar, which is a dominant species in plant communities distributed in the northern hemisphere, is commonly used as a model plant in forestry studies. Poplar production can be inhibited by infections caused by bacteria, including Lonsdalea quercina subsp. populi, which is a gram-negative bacterium responsible for bark canker disease. However, the molecular basis of the pathogenesis remains uncharacterized. In this study, we annotated the two-component signal transduction systems (TCSs) encoded by the L. quercina subsp. populi N-5-1 genome and identified 18 putative histidine kinases and 24 response regulators. A large-scale mutational analysis revealed that 19 TCS genes regulated bacterial virulence against poplar trees. Additionally, the deletion of kdpE or overexpression of kdpD resulted in almost complete loss of bacterial virulence. We observed that kdpE and kdpD formed a bi-cistronic operon. KdpD exhibited autokinase activity and could bind to KdpE (K<sub>d</sub> = 5.73 ± 0.64 μM). Furthermore, KdpE is an OmpR family response regulator. A chromatin immunoprecipitation sequencing analysis revealed that KdpE binds to an imperfect palindromic sequence within the promoters of 44 genes, including stress response genes Lqp0434, Lqp3037, and Lqp3270. A comprehensive analysis of TCS functions may help to characterize the regulation of poplar bark canker disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29424663</PMID><DateCompleted><Year>2018</Year><Month>08</Month><Day>03</Day></DateCompleted><DateRevised><Year>2018</Year><Month>08</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0894-0282</ISSN><JournalIssue CitedMedium="Print"><Volume>31</Volume><Issue>7</Issue><PubDate><Year>2018</Year><Month>07</Month></PubDate></JournalIssue><Title>Molecular plant-microbe interactions : MPMI</Title><ISOAbbreviation>Mol Plant Microbe Interact</ISOAbbreviation></Journal><ArticleTitle>A Large-Scale Mutational Analysis of Two-Component Signaling Systems of Lonsdalea quercina Revealed that KdpD-KdpE Regulates Bacterial Virulence Against Host Poplar Trees.</ArticleTitle><Pagination><MedlinePgn>724-736</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1094/MPMI-10-17-0248-R</ELocationID><Abstract><AbstractText>Poplar, which is a dominant species in plant communities distributed in the northern hemisphere, is commonly used as a model plant in forestry studies. Poplar production can be inhibited by infections caused by bacteria, including Lonsdalea quercina subsp. populi, which is a gram-negative bacterium responsible for bark canker disease. However, the molecular basis of the pathogenesis remains uncharacterized. In this study, we annotated the two-component signal transduction systems (TCSs) encoded by the L. quercina subsp. populi N-5-1 genome and identified 18 putative histidine kinases and 24 response regulators. A large-scale mutational analysis revealed that 19 TCS genes regulated bacterial virulence against poplar trees. Additionally, the deletion of kdpE or overexpression of kdpD resulted in almost complete loss of bacterial virulence. We observed that kdpE and kdpD formed a bi-cistronic operon. KdpD exhibited autokinase activity and could bind to KdpE (K<sub>d</sub> = 5.73 ± 0.64 μM). Furthermore, KdpE is an OmpR family response regulator. A chromatin immunoprecipitation sequencing analysis revealed that KdpE binds to an imperfect palindromic sequence within the promoters of 44 genes, including stress response genes Lqp0434, Lqp3037, and Lqp3270. A comprehensive analysis of TCS functions may help to characterize the regulation of poplar bark canker disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Ruo-Lan</ForeName><Initials>RL</Initials><AffiliationInfo><Affiliation>1 The College of Forestry, Beijing Forestry University, Beijing 100083, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>2 State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Chao-Ying</ForeName><Initials>CY</Initials><AffiliationInfo><Affiliation>2 State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Jin-Wei</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>2 State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>3 School of Biological Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>1 The College of Forestry, Beijing Forestry University, Beijing 100083, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Ai-Ning</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>1 The College of Forestry, Beijing Forestry University, Beijing 100083, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qian</LastName><ForeName>Wei</ForeName><Initials>W</Initials><Identifier Source="ORCID">0000-0002-7041-5354</Identifier><AffiliationInfo><Affiliation>2 State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; and.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>05</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mol Plant Microbe Interact</MedlineTA><NlmUniqueID>9107902</NlmUniqueID><ISSNLinking>0894-0282</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001426">Bacterial Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004269">DNA, Bacterial</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001426" MajorTopicYN="N">Bacterial Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004252" MajorTopicYN="N">DNA Mutational Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004269" MajorTopicYN="N">DNA, Bacterial</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015964" MajorTopicYN="N">Gene Expression Regulation, Bacterial</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006090" MajorTopicYN="N">Gram-Negative Bacteria</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>2</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>2</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29424663</ArticleId><ArticleId IdType="doi">10.1094/MPMI-10-17-0248-R</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Deng, Chao Ying" sort="Deng, Chao Ying" uniqKey="Deng C" first="Chao-Ying" last="Deng">Chao-Ying Deng</name><name sortKey="Qian, Wei" sort="Qian, Wei" uniqKey="Qian W" first="Wei" last="Qian">Wei Qian</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Ruo Lan" sort="Yang, Ruo Lan" uniqKey="Yang R" first="Ruo-Lan" last="Yang">Ruo-Lan Yang</name></noRegion><name sortKey="He, Wei" sort="He, Wei" uniqKey="He W" first="Wei" last="He">Wei He</name><name sortKey="Li, Ai Ning" sort="Li, Ai Ning" uniqKey="Li A" first="Ai-Ning" last="Li">Ai-Ning Li</name><name sortKey="Wei, Jin Wei" sort="Wei, Jin Wei" uniqKey="Wei J" first="Jin-Wei" last="Wei">Jin-Wei Wei</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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